Qian M, Johnson A E, Södersten P
Department of Clinical Neuroscience, Karolinska Institute, Novum, Huddinge, Sweden.
Neuroreport. 1998 Aug 24;9(12):2763-7. doi: 10.1097/00001756-199808240-00015.
Male rats were injected with 6-hydroxydopamine in the lateral hypothalamus and tested for ingestive behavior starting on the day after the injection. The rats did not eat food pellets but readily ingested an intraorally infused nutritive solution. If given three daily intraoral infusions, 6-hydroxydopamine-treated rats defended their body weight and were as sensitive to the inhibitory effect of cholecystokinin octapeptide on intake as controls. Dopamine was reduced by 94% in the dorsal striatum five days after the 6-hydroxydopamine injection. Noradrenaline and serotonin were less markedly affected. Thus, while appetitive ingestive behavior is disrupted, consummatory ingestive behavior and body weight regulatory competence are only marginally affected by massive damage to forebrain dopamine neural networks.
给雄性大鼠的下丘脑外侧注射6-羟基多巴胺，并在注射后的第二天开始测试其摄食行为。这些大鼠不吃食物颗粒，但很容易摄入经口灌注的营养溶液。如果每天进行三次经口灌注，6-羟基多巴胺处理的大鼠能够维持体重，并且对胆囊收缩素八肽对摄入量的抑制作用与对照组一样敏感。在注射6-羟基多巴胺五天后，背侧纹状体中的多巴胺减少了94%。去甲肾上腺素和5-羟色胺受到的影响较小。因此，虽然食欲性摄食行为受到破坏，但前脑多巴胺神经网络的大量损伤对终结性摄食行为和体重调节能力的影响很小。
