Hiltunen A J, Lafolie P, Martel J, Ottosson E C, Boreus L O, Beck O, Borg S, Hjemdahl P
Department of Clinical Neuroscience, St Göran's Hospital, Karolinska Institute, Stockholm, Sweden.
Psychopharmacology (Berl). 1995 Mar;118(2):122-6. doi: 10.1007/BF02245829.
Two rating scales, which were originally developed for measurements of objective and subjective signs of opiate withdrawal, were used to evaluate potential estimates (correlates) of methadone effects in relation to plasma methadone concentrations. Patients participating in our regular methadone maintenance treatment project were studied during 24 h after the intake of the daily methadone dose. Methadone concentrations in plasma were compared to the subjective (estimated by the patients) and objective (estimated by the investigator) signs of the drug effects before, and 2.5, 5, 9 and 24 h after intake of methadone. Some new items possibly related to rising methadone concentrations were added to the subjective scale. Results indicated that, for subjective ratings, the majority of the items investigated corresponded well with the plasma methadone concentrations. The most significant associations were found for the following items: low psychomotor speed, alertness, running nose, yawning and anxiety. For objective ratings, only the items rhinorrhea, piloerection and signs of anxiety were significantly associated with the methadone concentrations. These rating scales may, together with plasma methadone determinations, be of considerable value when making dose adjustments for methadone maintenance patients. Further work is, however, needed to establish concentration-effect relationships.
两种最初用于测量阿片戒断客观和主观体征的评定量表，被用于评估美沙酮效应与血浆美沙酮浓度相关的潜在估计值（相关因素）。参与我们常规美沙酮维持治疗项目的患者，在服用每日美沙酮剂量后的24小时内接受研究。将血浆中美沙酮浓度与服用美沙酮前以及服用后2.5、5、9和24小时药物效应的主观体征（由患者估计）和客观体征（由研究者估计）进行比较。在主观量表中添加了一些可能与美沙酮浓度升高相关的新项目。结果表明，对于主观评分，大多数被调查项目与血浆美沙酮浓度相符。在以下项目中发现了最显著的相关性：心理运动速度减慢、警觉性、流鼻涕、打哈欠和焦虑。对于客观评分，只有流鼻涕、竖毛和焦虑体征与美沙酮浓度显著相关。这些评定量表与血浆美沙酮测定一起，在为美沙酮维持治疗患者调整剂量时可能具有相当大的价值。然而，需要进一步开展工作来建立浓度-效应关系。
