Feldman S A, Wu X, England A
Magill Department of Anaesthetics, Chelsea and Westminster Hospital, London.
Anaesthesia. 1995 Jun;50(6):510-3. doi: 10.1111/j.1365-2044.1995.tb06041.x.
There is evidence that onset time and potency of non-depolarising neuromuscular blocking drugs are related. The relationship between onset time and rate of recovery has not been investigated. In this study, using the isolated forearm technique, the onset time of four different non-depolarising drugs have been compared with their recovery times. It has been demonstrated that there is a strong relationship between these parameters. It is proposed that the relationship between onset time and offset time suggests a common mechanism that influences both events and that this may also explain the relationship between potency and the rate of onset.
有证据表明，非去极化神经肌肉阻滞药物的起效时间和效能相关。起效时间与恢复速率之间的关系尚未得到研究。在本研究中，采用离体前臂技术，对四种不同非去极化药物的起效时间与其恢复时间进行了比较。结果表明，这些参数之间存在密切关系。有人提出，起效时间和消退时间之间的关系提示存在一种影响这两个事件的共同机制，这也可能解释效能与起效速率之间的关系。
