Mugnier E, Ployard F, Roy M P, Fermanian J, Rappaport R
Arch Fr Pediatr. 1985 Oct;42(8):671-6.
Twenty-six children below age 7 years with idiopathic growth hormone deficiency have been treated with hGH for 2 years. Bone ages were inferior to 3 years and growth retardation averaged 3.9 +/- 0.9 standard deviation (SD) below the population mean. Results were compared to those obtained in a control group of 29 prepubertal patients, aged more than 7 years, and treated with hGH according to the same protocol. The mean height gains during the first and second year of treatment were respectively 8.4 +/- 1.8 cm and 6.6 +/- 1.5 cm. These values are significantly higher than those obtained in the group of older children. However within 2 years of treatment the initial catch-up in height of 0.9 +/- 0.6 DS was not different. In conclusion, we did not observe a better catch up growth in children before 7 years of age than in older prepubertal children, in spite of using higher doses of hGH.
26名7岁以下特发性生长激素缺乏症儿童接受了2年的人生长激素（hGH）治疗。骨龄小于3岁，生长迟缓平均比人群均值低3.9±0.9个标准差（SD）。将结果与29名7岁以上青春期前患者的对照组进行比较，这些患者按照相同方案接受hGH治疗。治疗第一年和第二年的平均身高增长分别为8.4±1.8厘米和6.6±1.5厘米。这些数值显著高于年龄较大儿童组。然而，在治疗的2年内，初始身高追赶0.9±0.6DS并无差异。总之，尽管使用了更高剂量的hGH，但我们并未观察到7岁前儿童的追赶生长比青春期前年龄较大儿童更好。
