Boersma B, Wynne H J, Wit J M
Department of Pediatrics, University Hospital Leiden, The Netherlands.
Acta Paediatr. 1994 Oct;83(10):1097-9. doi: 10.1111/j.1651-2227.1994.tb12994.x.
Celiac disease may lead to various degrees of growth retardation. In general, catch-up growth is completed in the first 2 years after the start of therapy. A mathematical model for catch-up growth in celiac disease can be useful as a reference to which the growth pattern observed during treatment of other conditions can be compared. In this study we performed a non-linear regression analysis on individual growth data of 16 celiac disease patients using a monomolecular growth function. The goodness of fit was significant in all cases (p < 0.05), which illustrates that this function adequately describes catch-up growth in individuals with celiac disease. From the individual models we have composed a cross-sectional curve and a longitudinal description of the pattern of catch-up growth for the entire population.
乳糜泻可能导致不同程度的生长发育迟缓。一般来说，追赶生长在治疗开始后的头两年内完成。乳糜泻追赶生长的数学模型可作为一个参考，用于比较在治疗其他病症期间观察到的生长模式。在本研究中，我们使用单分子生长函数对16例乳糜泻患者的个体生长数据进行了非线性回归分析。在所有情况下拟合优度均显著（p < 0.05），这表明该函数能充分描述乳糜泻患者个体的追赶生长情况。从个体模型中，我们构建了一条横断面曲线以及对整个人群追赶生长模式的纵向描述。
