Moss M E, Kanarek M S, Anderson H A, Hanrahan L P, Remington P L
Eastman Dental Center, Rochester, New York, USA.
Arch Environ Health. 1995 May-Jun;50(3):235-41. doi: 10.1080/00039896.1995.9940393.
Proxy exposure measures and readily available data from the Wisconsin Cancer Reporting System were used to contrast 167 osteosarcoma cases with 989 frequency-matched cancer referents reported during 1979-1989. Differences in potential exposure to water-borne radiation and fluoridated drinking water, population size for the listed place of residence, and seasonality were assessed. An association was found between osteosarcoma and residence in a population of less than 9,000 (odds ratio = 1.6, 95% confidence interval = 1.1-2.4). In addition, an association between month of birth (May through July versus other months of birth) and osteosarcoma among individuals who were less than 25 y of age (odds ratio = 1.9, 95% confidence interval = 1.1-3.4). Overall, no association was found between potential exposure to fluoridated drinking water and osteosarcoma (odds ratio = 1.0, 95% confidence interval = 0.6-1.5). The association between osteosarcoma and water-borne radiation was weak and was not significant statistically (odds ratio = 1.5, 95% confidence interval = 0.8-2.8).
采用代理暴露测量方法以及来自威斯康星癌症报告系统的现成数据，对1979年至1989年期间报告的167例骨肉瘤病例与989例频率匹配的癌症对照进行对比。评估了潜在的水传播辐射暴露和氟化饮用水暴露、所列居住地的人口规模以及季节性方面的差异。发现骨肉瘤与居住在人口不足9000人的地区之间存在关联（优势比=1.6，95%置信区间=1.1-2.4）。此外，在年龄小于25岁的个体中，出生月份（5月至7月与其他出生月份）与骨肉瘤之间存在关联（优势比=1.9，95%置信区间=1.1-3.4）。总体而言，未发现氟化饮用水潜在暴露与骨肉瘤之间存在关联（优势比=1.0，95%置信区间=0.6-1.5）。骨肉瘤与水传播辐射之间的关联较弱，且在统计学上不显著（优势比=1.5，95%置信区间=0.8-2.8）。
