女性伴侣体内抗精子抗体对体内和体外妊娠及自然流产率的影响。
The effect of sera antisperm antibodies in the female partner on in vivo and in vitro pregnancy and spontaneous abortion rates.
作者信息
Check J H, Katsoff D, Bollendorf A, Callan C
机构信息
University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, USA.
出版信息
Am J Reprod Immunol. 1995 Jan;33(1):131-3. doi: 10.1111/j.1600-0897.1995.tb01149.x.
PROBLEM
To determine the incidence of antisperm antibodies (ASA) in female sera from infertile couples or those suffering from recurrent abortions. Also to determine if the pregnancy and/or abortion rates are any higher in those positive versus those negative for ASA.
METHOD
All registered patients had sera drawn and ASA measured by indirect immunobead test on initial study. Pregnancy and abortion rates were determined for patients undergoing in vivo or in vitro therapy.
RESULTS
There was a low incidence of ASA in patients having in vivo or in vitro treatment. There was no decrease in pregnancy rates (PRs) or increase in spontaneous abortions (SAB) in those positive for ASA.
CONCLUSION
Antisperm antibodies in female sera do not seem to be etiologic in causing infertility or SAB. Future studies might consider changing the antigen source from donor sperm to husband's sperm.
问题
确定不育夫妇或反复流产女性血清中抗精子抗体（ASA）的发生率。同时确定ASA阳性者与阴性者相比，妊娠和/或流产率是否更高。
方法
所有登记患者在初始研究时采血，通过间接免疫珠试验检测ASA。对接受体内或体外治疗的患者确定妊娠和流产率。
结果
接受体内或体外治疗的患者中ASA发生率较低。ASA阳性者的妊娠率（PRs）没有降低，自然流产（SAB）也没有增加。
结论
女性血清中的抗精子抗体似乎不是导致不育或自然流产的病因。未来的研究可能会考虑将抗原来源从供体精子改为丈夫的精子。
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