辛伐他汀和普伐他汀治疗对高胆固醇血症患者认知功能的影响。
Effects of treatment with simvastatin and pravastatin on cognitive function in patients with hypercholesterolaemia.
作者信息
Cutler N, Sramek J, Veroff A, Block G, Stauffer L, Lines C
机构信息
California Clinical Trials, Beverly Hills 90211, USA.
出版信息
Br J Clin Pharmacol. 1995 Mar;39(3):333-6. doi: 10.1111/j.1365-2125.1995.tb04458.x.
Abstract
The effects of equi-efficacious doses of the cholesterol-lowering drugs simvastatin (20 mg day-1) and pravastatin (40 mg day-1) on tests of cognitive function were investigated in a double-blind, placebo-controlled, 2-period (4 weeks per period), incomplete block, crossover study of 36 patients (24 per treatment) with hypercholesterolaemia. After 4 weeks neither of the active treatments differed significantly from placebo on any cognitive measure.
摘要
在一项双盲、安慰剂对照、两阶段（每个阶段4周）、不完全区组、交叉研究中，对36例高胆固醇血症患者（每种治疗24例），研究了等效剂量的降胆固醇药物辛伐他汀（20毫克/天）和普伐他汀（40毫克/天）对认知功能测试的影响。4周后，在任何认知指标上，两种活性治疗与安慰剂相比均无显著差异。
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