Veroff A E, Cutler N R, Sramek J J, Prior P L, Mickelson W, Hartman J K
California Clinical Trials, Beverly Hills.
J Geriatr Psychiatry Neurol. 1991 Oct-Dec;4(4):211-7. doi: 10.1177/089198879100400406.
The Computerized Neuropsychological Test Battery (CNTB), a new assessment tool for neuropsychopharmacologic research, is based on a neuropsychological approach. While it is based on tests previously shown to be sensitive to subtle changes in neuropsychological functioning, it differs from currently available tools for measuring central nervous system effects of new compounds. It has sensitivity to a broader range of cognitive functioning and is more comprehensive than other measurements in its sampling of neuropsychological functions, providing wider application to diverse clinical populations. The CNTB is valid, reliable, and has two alternative forms. Use of the computer as an expert system maximizes standardization and ease of CNTB administration and data analysis. Using this assessment tool, three groups of subjects were compared: young and elderly neurologically normal subjects and elderly subjects with the dementia syndrome of Alzheimer's disease (AD). The AD subjects' summary score on the CNTB correlated significantly with the Blessed Information Memory Concentration Test score. The CNTB summary score was significantly higher in young subjects than in neurologically normal elderly subjects, demonstrating sensitivity to the effects of aging. The CNTB summary score also was significantly higher in neurologically normal elderly subjects than in elderly subjects with AD dementia.
计算机化神经心理测试组合（CNTB）是一种用于神经精神药理学研究的新型评估工具，它基于神经心理学方法。虽然它基于先前已证明对神经心理功能细微变化敏感的测试，但它与目前用于测量新化合物对中枢神经系统影响的现有工具不同。它对更广泛的认知功能具有敏感性，并且在神经心理功能抽样方面比其他测量方法更全面，从而能够更广泛地应用于不同的临床人群。CNTB有效、可靠，并有两种替代形式。将计算机用作专家系统可最大限度地提高CNTB管理和数据分析的标准化程度及便捷性。使用此评估工具，对三组受试者进行了比较：年轻和年长的神经功能正常受试者以及患有阿尔茨海默病（AD）痴呆综合征的年长受试者。AD受试者在CNTB上的总分与布列斯德信息记忆浓度测试得分显著相关。年轻受试者的CNTB总分显著高于神经功能正常的年长受试者，表明该测试对衰老效应敏感。神经功能正常的年长受试者的CNTB总分也显著高于患有AD痴呆的年长受试者。
