Lacey S W
Division of Gastroenterology, University of Texas-Southwestern Medical Center at Dallas, USA.
Clin Infect Dis. 1995 May;20(5):1409-19. doi: 10.1093/clinids/20.5.1409.
From the pandemics of the 19th century to the recent disaster in Goma, Zaire, cholera has left an indelible mark on human and medical history. Cholera pandemics in the 19th and 20th centuries drove the development of epidemiology as a serious science. Cholera has continued to press advances in the concepts of disease ecology, basic membrane biology, and transmembrane signaling and in the application of scientific information to treatment design. Furthermore, the lessons learned from the study of pandemic cholera are likely to provide insights into the best means of stopping other pandemics. In spite of tremendous scientific and clinical progress, however, the seventh pandemic has lasted 33 years, and the eighth pandemic appears to have started.
从19世纪的大流行到最近扎伊尔戈马的灾难，霍乱在人类和医学史上留下了不可磨灭的印记。19世纪和20世纪的霍乱大流行推动了流行病学成为一门严肃科学的发展。霍乱继续推动疾病生态学、基础膜生物学和跨膜信号传导概念的进步，以及科学信息在治疗设计中的应用。此外，从大流行霍乱研究中吸取的经验教训可能会为阻止其他大流行的最佳方法提供见解。然而，尽管取得了巨大的科学和临床进展，第七次大流行已经持续了33年，而第八次大流行似乎已经开始。
