Jenkinson E J, Anderson G, Moore N C, Smith C A, Owen J J
Department of Anatomy, Medical School, University of Birmingham, U.K.
Dev Immunol. 1994;3(4):265-71. doi: 10.1155/1994/75434.
We have investigated the possibility that the costimulatory signals required for activation of mature T cells also play a role in providing differentiation signals for positive selection during T-cell development. We show that purified MHC Class II+ thymic epithelial cells are able to support positive selection in vitro but lack both the functional capacity to deliver costimulatory signals and expression of the costimulatory ligand B7. Our results suggest that the additional signals provided by costimulatory ligands are not required for TCR-mediated positive selection, although other ancillary signals provided by thymic epithelial cells may be involved.
我们研究了成熟T细胞激活所需的共刺激信号在T细胞发育过程中为阳性选择提供分化信号方面是否也发挥作用。我们发现，纯化的MHC II类+胸腺上皮细胞能够在体外支持阳性选择，但缺乏传递共刺激信号的功能能力以及共刺激配体B7的表达。我们的结果表明，共刺激配体提供的额外信号并非TCR介导的阳性选择所必需，尽管胸腺上皮细胞提供的其他辅助信号可能参与其中。
