Garritson B K, Nikaein A, Peters G N, Gorman M A, King C C, Liepa G U
Cancer Pract. 1995 Jul-Aug;3(4):239-46.
A pilot study was conducted to evaluate the effect of diet on immune function in nine premenopausal, post-therapy patients with breast cancer. The patients were instructed on following the American Cancer Society dietary guidelines and were told to do so from day 0 to day 28. These guidelines recommend a high-fiber, low-fat diet. On day 29, the patients continued the diet but included fish high in omega-3 fatty acids until day 56. Twenty-four-hour urine and blood samples, and 3-day diet records were obtained on days 0, 28, and 56. The following parameters were monitored: lymphocyte subsets, T-cell function (proliferation and cytolytic response), and urinary prostaglandin E2 (PGE2). Results throughout the study suggested a benefit from decreasing dietary fat intake, and increasing fish intake. Helper T-cell (CD4) percentage increased from day 0 to days 28 and 56 (P = 0.048). Cytotoxic/suppressor T-cell (CD8) percentage decreased from day 0 to days 28 and 56 (P = 0.002). The CD4/CD8 cell ratio increased by days 28 and 56 (P = 0.0004). The proliferation of CD4 cells increased from day 0 to days 28 and 56 (P = 0.005). Significant changes were not found in the cytolytic activity of T cells, natural killer cells, total T and B cells, or urinary prostaglandin E2. Results suggest that patients with breast cancer may benefit from following American Cancer Society dietary guidelines and consuming cold-water ocean fish.
开展了一项初步研究，以评估饮食对9名绝经前、乳腺癌治疗后的患者免疫功能的影响。患者接受了遵循美国癌症协会饮食指南的指导，并被告知从第0天至第28天遵循这些指南。这些指南推荐高纤维、低脂肪饮食。在第29天，患者继续该饮食，但加入富含ω-3脂肪酸的鱼类，直至第56天。在第0天、第28天和第56天采集了24小时尿液和血液样本以及3天的饮食记录。监测了以下参数：淋巴细胞亚群、T细胞功能（增殖和细胞溶解反应）以及尿前列腺素E2（PGE2）。整个研究结果表明，减少饮食脂肪摄入和增加鱼类摄入有益处。辅助性T细胞（CD4）百分比从第0天到第28天和第56天有所增加（P = 0.048）。细胞毒性/抑制性T细胞（CD8）百分比从第0天到第28天和第56天有所下降（P = 0.002）。CD4/CD8细胞比率在第28天和第56天有所增加（P = 0.0004）。CD4细胞的增殖从第0天到第28天和第56天有所增加（P = 0.005）。在T细胞、自然杀伤细胞、总T细胞和B细胞的细胞溶解活性或尿前列腺素E2方面未发现显著变化。结果表明，乳腺癌患者遵循美国癌症协会饮食指南并食用冷水海洋鱼类可能有益。
