Gogos C A, Ginopoulos P, Zoumbos N C, Apostolidou E, Kalfarentzos F
Department of Medicine, Patras University, Medical School, Greece.
Cancer Detect Prev. 1995;19(5):415-7.
The effect of omega-3 polyunsaturated fatty acids (PUFA) on the immune system seems to be beneficial. There has been a number of studies concerning the effect of dietary omega-3 PUFA on different immune parameters. The aim of our present study was to investigate the effect of dietary omega-3 PUFA on T-cell subsets and natural killer (NK) cells of patients with solid tumors. We studied 20 patients with solid tumors who received 18 g fish oil/day for 40 consecutive days. We detected a significant increase in T-helper/T-suppressor cell ratio 40 days into omega-3 supplementation, due mainly to a decrease in the number of suppressor T cells. We concluded that dietary omega-3 fatty acids may have a beneficial effect on the already compromised immune system of patients suffering from solid tumors.
ω-3多不饱和脂肪酸（PUFA）对免疫系统似乎具有有益作用。已经有许多关于膳食ω-3 PUFA对不同免疫参数影响的研究。我们当前研究的目的是调查膳食ω-3 PUFA对实体瘤患者T细胞亚群和自然杀伤（NK）细胞的影响。我们研究了20名实体瘤患者，他们连续40天每天摄入18克鱼油。在补充ω-3 40天后，我们检测到辅助性T细胞/抑制性T细胞比例显著增加，这主要是由于抑制性T细胞数量减少。我们得出结论，膳食ω-3脂肪酸可能对患有实体瘤的患者本已受损的免疫系统具有有益作用。
