Lodge N, Evans M L, Wilkins M, Blake P R, Fryatt I
Eur J Cancer Care (Engl). 1995 Mar;4(1):8-10. doi: 10.1111/j.1365-2354.1995.tb00046.x.
Diarrhoea is the commonest acute complication during radiotherapy treatment to the pelvis. Codeine phosphate and a low residue diet is the standard therapy for radiation-induced diarrhoea at The Royal Marsden NHS Trust. The hypothesis put forward was that Ispaghulahusk and codeine phosphate were equally effective in the treatment of diarrhoea during radiotherapy. Participants in the study were female patients who had experienced change of bowel habit whilst receiving radiotherapy for their gynaecological cancer. Quantitative data was collected from patient diaries and treatment flow-sheets. Ten patients were randomized into the trial, five to codeine phosphate, and five to Ispaghulahusk. Continuing the trial was questioned after 10 patients had been treated. All five patients in the codeine phosphate arm received adequate control, while the five patients allocated to the Ispaghulahusk arm were all crossed-over to codeine phosphate with resolution of their diarrhoea. The results show that Ispaghulahusk, whilst not totally ineffective at controlling diarrhoea, was significantly less effective than codeine phosphate. Our conclusion is that there is insufficient reason to change to a less effective and less palatable preparation for the control of radiation-induced diarrhoea.
腹泻是盆腔放疗期间最常见的急性并发症。在皇家马斯登国民保健服务信托基金，磷酸可待因和低残渣饮食是放射性腹泻的标准治疗方法。提出的假设是，卵叶车前子壳和磷酸可待因在放疗期间治疗腹泻方面同样有效。该研究的参与者是在接受妇科癌症放疗期间出现排便习惯改变的女性患者。定量数据从患者日记和治疗流程表中收集。10名患者被随机纳入试验，5名使用磷酸可待因，5名使用卵叶车前子壳。在治疗了10名患者后，继续试验受到了质疑。磷酸可待因组的所有5名患者都得到了充分的控制，而分配到卵叶车前子壳组的5名患者都改用了磷酸可待因，腹泻得到缓解。结果表明，卵叶车前子壳虽然在控制腹泻方面并非完全无效，但明显不如磷酸可待因有效。我们的结论是，没有足够的理由改用效果较差且口感较差的制剂来控制放射性腹泻。
