FUT-175对白细胞介素8和多形核白细胞弹性蛋白酶产生的抑制作用。
Inhibitory effect of FUT-175 on the production of interleukin 8 and polymorphonuclear leukocyte elastase.
作者信息
Kikuchi M, Endo S, Inada K, Yamashita H, Takakuwa T, Nakae H, Kasai T, Baba N, Yamada Y
机构信息
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
出版信息
Res Commun Mol Pathol Pharmacol. 1995 Mar;87(3):269-74.
We investigated the inhibitory effects of a protease inhibitor, FUT-175, on the production of interleukin 8 (IL-8) and polymorphonuclear leukocyte elastase (PMNE) by polymorphonuclear leukocytes (PMN) and vascular endothelial cells. IL-8 production by PMN and vascular endothelial cells stimulated with lipopolysaccharide (LPS) was inhibited by FUT-175. This compound also inhibited PMNE production by PMN following LPS stimulation.
我们研究了蛋白酶抑制剂FUT-175对多形核白细胞（PMN）和血管内皮细胞产生白细胞介素8（IL-8）及多形核白细胞弹性蛋白酶（PMNE）的抑制作用。FUT-175抑制了脂多糖（LPS）刺激的PMN和血管内皮细胞产生IL-8。该化合物还抑制了LPS刺激后PMN产生PMNE。
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