Dens F, Boute P, Vinckier F, Declerck D
Department of Dentistry, Free University of Brussels, Belgium.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Jun;79(6):701-4. doi: 10.1016/s1079-2104(05)80303-8.
Chemotherapy influences the human immune system. Salivary alterations occur during cancer treatment. In this article we examine the salivary immunoglobulin content in pediatric patients who were long-term event-free and correlate these findings with different oral factors.
Fifty-two children of a study group and 63 children of a control group were examined at our University Hospital. Caries prevalence and plaque index were scored. Whole saliva samples were taken for determination of slgA and IgG concentrations and Streptococcus mutans and Lactobacillus counts. For statistical analysis the Dental Survey Plus (Providence Software Services, Bristol, England) software package was used.
Concentrations of slgA and IgG were within normal limits in both groups; slgA level increased with age. A negative correlation between slgA concentration and caries experience was not found in all age groups. No correlation with other salivary parameters was found.
Salivary content of slgA and IgG can return to normal after cytotoxic therapy in these children. Salivary IgA seem to play a role in the development of dental caries in this population.
化疗会影响人体免疫系统。癌症治疗期间会出现唾液改变。在本文中，我们研究了长期无事件发生的儿科患者的唾液免疫球蛋白含量，并将这些发现与不同的口腔因素相关联。
我们大学医院对研究组的52名儿童和对照组的63名儿童进行了检查。对龋齿患病率和菌斑指数进行评分。采集全唾液样本以测定分泌型IgA（slgA）和IgG浓度以及变形链球菌和乳酸杆菌计数。使用Dental Survey Plus（英国布里斯托尔普罗维登斯软件服务公司）软件包进行统计分析。
两组中slgA和IgG的浓度均在正常范围内；slgA水平随年龄增长而升高。并非在所有年龄组中都发现slgA浓度与龋齿经历之间存在负相关。未发现与其他唾液参数相关。
这些儿童在细胞毒性治疗后，唾液中slgA和IgG的含量可恢复正常。唾液IgA似乎在该人群的龋齿发展中起作用。
