Gråhn E, Tenovuo J, Lehtonen O P, Eerola E, Vilja P
Turku Naval Base, Finland.
Acta Odontol Scand. 1988 Apr;46(2):67-74. doi: 10.3109/00016358809004749.
The association of salivary antibody (total IgA, IgG, and IgM and antibodies reactive with Streptococcus mutans) and non-antibody (lysozyme, lactoferrin, salivary peroxidase, myeloperoxidase, hypothiocyanite, thiocyanate) defense factors with oral health (past and present dental caries, gingival bleeding, the number of salivary S. mutans and lactobacilli) were studied in 50 naval recruits. Dental caries was significantly associated with large amounts of S. mutans, lactobacilli, and total salivary immunoglobulins and with low salivary flow rate and buffer capacity. Salivary anti-S. mutans antibodies did not correlate with dental caries or S. mutans levels. Moreover, none of the salivary non-antibody factors alone had any strong relationship to dental caries or S. mutans levels. Gingival inflammation was associated with elevated levels of lysozyme in whole saliva. It is concluded that in adults the associations between single-point measurements of most salivary antimicrobial constituents and the factors describing oral health are weak.
对50名海军新兵的唾液抗体（总IgA、IgG和IgM以及与变形链球菌反应的抗体）和非抗体（溶菌酶、乳铁蛋白、唾液过氧化物酶、髓过氧化物酶、次硫氰酸盐、硫氰酸盐）防御因子与口腔健康（过去和现在的龋齿、牙龈出血、唾液中变形链球菌和乳酸菌的数量）之间的关联进行了研究。龋齿与大量变形链球菌、乳酸菌、唾液总免疫球蛋白显著相关，与唾液流速低和缓冲能力低也显著相关。唾液抗变形链球菌抗体与龋齿或变形链球菌水平无关。此外，唾液中的非抗体因子单独与龋齿或变形链球菌水平均无强烈关联。牙龈炎症与全唾液中溶菌酶水平升高有关。得出的结论是，在成年人中，大多数唾液抗菌成分的单点测量值与描述口腔健康的因素之间的关联较弱。
