Fogari R, Zoppi A, Marasi G, Vanasia A, Villa G
Department of Internal Medicine and Therapeutics, University of Pavia, Italy.
J Cardiovasc Risk. 1994 Dec;1(4):341-5.
Fibrinogen levels are reported to be elevated in hypertensive patients and tend to cluster with nearly all other established cardiovascular risk factors. The aim of this study was to evaluate the relationship between plasma fibrinogen and a number of other cardiovascular risk factors in patients with essential hypertension.
We studied 118 men with essential hypertension, aged 18-65 years. The clinical evaluation included measurements of blood pressure (mercury sphygmomanometer, Korotkoff I and V), levels of plasma fibrinogen, total cholesterol, high-density-lipoprotein (HDL) cholesterol, triglycerides and blood glucose and the ratio of total-cholesterol to HDL-cholesterol levels; a detailed history of medical and personal habits was also recorded.
As expected, plasma fibrinogen levels were significantly higher in smokers than in non-smokers, with the number of cigarettes smoked correlating positively with the fibrinogen level. Patients with a total-cholesterol level in excess of 220 mg/dl had significantly higher fibrinogen levels, and both univariate and multivariate analyses showed total-cholesterol and fibrinogen levels to be positively correlated. A weaker but significant relationship was noted between the fibrinogen level and triglyceride levels (P = 0.0017) and between the fibrinogen level and the ratio of total-cholesterol to HDL-cholesterol levels (P = 0.0006). Fibrinogen levels were not significantly associated with either systolic or diastolic blood pressures.
A family history of hypertension appears to potentiate the tendency of fibrinogen to cluster with other cardiovascular risk factors in hypertensive patients.
据报道，高血压患者的纤维蛋白原水平升高，并且几乎倾向于与所有其他已确定的心血管危险因素聚集在一起。本研究的目的是评估原发性高血压患者血浆纤维蛋白原与其他一些心血管危险因素之间的关系。
我们研究了118名年龄在18至65岁之间的原发性高血压男性患者。临床评估包括测量血压（汞柱式血压计，柯氏音第一音和第五音）、血浆纤维蛋白原水平、总胆固醇、高密度脂蛋白（HDL）胆固醇、甘油三酯和血糖以及总胆固醇与HDL胆固醇水平的比值；还记录了详细的病史和个人习惯。
正如预期的那样，吸烟者的血浆纤维蛋白原水平明显高于非吸烟者，吸烟数量与纤维蛋白原水平呈正相关。总胆固醇水平超过220mg/dl的患者纤维蛋白原水平明显更高，单因素和多因素分析均显示总胆固醇和纤维蛋白原水平呈正相关。纤维蛋白原水平与甘油三酯水平之间（P = 0.0017）以及纤维蛋白原水平与总胆固醇与HDL胆固醇水平的比值之间（P = 0.0006）存在较弱但显著的关系。纤维蛋白原水平与收缩压或舒张压均无显著关联。
高血压家族史似乎会增强高血压患者中纤维蛋白原与其他心血管危险因素聚集的趋势。
