Mosihuzzaman M, Nahar N, Ali L, Rokeya B, Khan A K, Nur-E-Alam M, Nandi R P
Department of Chemistry, University of Dhaka, Bangladesh.
Diabetes Res. 1994;26(3):127-38.
Rhizome of Costus speciosus, tuber of Nephrolepsis tuberosa, and bulb of Stephania hernandifolia, used by the local people and traditional healers in the Eastern Himalayan belt, were studied for their effects on serum glucose levels in nondiabetic and diabetic rat models at different prandial states. The results showed that in nondiabetic rat C speciosus and N tuberosa had no significant effect in the fasting or postprandial state when freeze-dried juices were fed simultaneously with glucose. However, when fed 30 min before the glucose load both C speciosus (p < 0.05) and N tuberosa (p < 0.003) showed hypoglycemic effect. To the contrary, S hernandifolia increased the serum glucose levels of nondiabetic rats in all the series of experiments (p < 0.05 or p < 0.01). In NIDDM model rats N tuberosa opposed the rise in serum glucose level when it was fed 30 min before the glucose load (p < 0.02), whereas S hernandifolia had a tendency to raise the serum glucose level. In IDDM model rats, none of these three freeze-dried juice showed any effect in the fasting state. However, C speciosus showed significant hypoglycemic effect (p < 0.002) when the juice was fed with simultaneous glucose load. In marked contrast to the findings with nondiabetic and NIDDM model rats S hernandifolia showed significant hypoglycemic effect (p < 0.05-0.006) in both the stages (fed simultaneously with, and 30 min before the glucose load) of prandial states of the IDDM model rats. The results indicated that these three plants have interesting possibilities as a source of oral hypoglycemic agents.
喜马拉雅东部地区的当地居民和传统治疗师使用的闭鞘姜根茎、块茎肾蕨块茎和千金藤鳞茎，在非糖尿病和糖尿病大鼠模型的不同用餐状态下，对其血清葡萄糖水平的影响进行了研究。结果表明，在非糖尿病大鼠中，当与葡萄糖同时喂食冻干汁液时，闭鞘姜和块茎肾蕨在空腹或餐后状态下均无显著影响。然而，在葡萄糖负荷前30分钟喂食时，闭鞘姜（p < 0.05）和块茎肾蕨（p < 0.003）均显示出降血糖作用。相反，在所有系列实验中，千金藤均提高了非糖尿病大鼠的血清葡萄糖水平（p < 0.05或p < 0.01）。在非胰岛素依赖型糖尿病（NIDDM）模型大鼠中，在葡萄糖负荷前30分钟喂食块茎肾蕨时，其可对抗血清葡萄糖水平的升高（p < 0.02），而千金藤则有升高血清葡萄糖水平的趋势。在胰岛素依赖型糖尿病（IDDM）模型大鼠中，这三种冻干汁液在空腹状态下均无任何作用。然而，当与葡萄糖同时喂食时，闭鞘姜显示出显著的降血糖作用（p < 0.002）。与非糖尿病和NIDDM模型大鼠的研究结果形成鲜明对比的是，在IDDM模型大鼠用餐状态的两个阶段（与葡萄糖同时喂食以及在葡萄糖负荷前30分钟喂食），千金藤均显示出显著的降血糖作用（p < 0.05 - 0.006）。结果表明，这三种植物作为口服降糖药来源具有有趣的可能性。
