Ali L, Azad Khan A K, Hassan Z, Mosihuzzaman M, Nahar N, Nasreen T, Nur-e-Alam M, Rokeya B
Planta Med. 1995 Aug;61(4):358-60. doi: 10.1055/s-2006-958100.
The whole powder of Trigonella foenum graecum seeds and its extracts were tested for their hypoglycemic effect on normal and diabetic model rats. The powder, its methanol extract, and the residue remaining after methanol extraction had significant hypoglycemic effects when fed simultaneously with glucose. The water extract of the methanol extractive-free residue of the seed powder showed significant hypoglycemic activity at different prandial states. The Soluble Dietary Fibre (SDF) fraction showed no effect on the fasting blood glucose levels of nondiabetic or NIDDM model rats. However, when fed simultaneously with glucose, it showed a significant hypoglycemic effect (p < 0.05) in NIDDM model rats. Chemical analysis showed that the major constituent of the SDF is a galactomannan. The results confirm the involvement of SDF in the hypoglycemic effect of T. foenum graecum seeds. However, compound(s) other than SDF is (are) also involved in the hypoglycemic activity.
对胡芦巴种子全粉及其提取物对正常和糖尿病模型大鼠的降血糖作用进行了测试。当与葡萄糖同时喂食时，该粉末、其甲醇提取物以及甲醇提取后剩余的残渣具有显著的降血糖作用。种子粉末无甲醇提取物的水提取物在不同用餐状态下显示出显著的降血糖活性。可溶性膳食纤维（SDF）部分对非糖尿病或非胰岛素依赖型糖尿病（NIDDM）模型大鼠的空腹血糖水平没有影响。然而，当与葡萄糖同时喂食时，它在NIDDM模型大鼠中显示出显著的降血糖作用（p < 0.05）。化学分析表明，SDF的主要成分是一种半乳甘露聚糖。结果证实SDF参与了胡芦巴种子的降血糖作用。然而，除SDF之外的其他化合物也参与了降血糖活性。
