Gonsebatt M E, Salazar A M, Montero R, Díaz Barriga F, Yáñez L, Gómez H, Ostrosky-Wegman P
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria.
Environ Health Perspect. 1995 Feb;103 Suppl 1(Suppl 1):111-3. doi: 10.1289/ehp.95103s1111.
Chromosomal aberration and sister chromatid exchange (SCE) frequencies were determined in lymphocytes cultured from 12 high-risk individuals working at a landfill for hazardous waste disposal. Cell proliferation kinetics (CPK) was also determined. Compared with 7 control individuals, no effects were observed with respect to SCE nor on CPK. However, the workers exhibited significantly higher frequencies of chromatid and chromosomal deletions, the magnitude of which was related with exposure time. This study suggests that when high-risk exposure is suspected, determining biomarkers of genotoxic damage (e.g., chromosomal aberrations), is useful for risk assessments.
对在危险废物处理垃圾填埋场工作的12名高危个体的淋巴细胞进行染色体畸变和姐妹染色单体交换（SCE）频率测定。同时也测定了细胞增殖动力学（CPK）。与7名对照个体相比，未观察到SCE和CPK有任何影响。然而，这些工人的染色单体和染色体缺失频率显著更高，其程度与暴露时间有关。这项研究表明，当怀疑存在高风险暴露时，确定遗传毒性损伤的生物标志物（如染色体畸变），对风险评估是有用的。
