编码人血清淀粉样蛋白A蛋白SAA1和SAA2的基因位于相距18 kb的相反转录方向上。
Genes encoding human serum amyloid A proteins SAA1 and SAA2 are located 18 kb apart in opposite transcriptional orientations.
作者信息
Kluve-Beckerman B, Song M
机构信息
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA.
出版信息
Gene. 1995 Jul 4;159(2):289-90. doi: 10.1016/0378-1119(95)00027-4.
The three expressed genes of the human serum amyloid A gene family (SAA1, SAA2 and SAA4) have been isolated in four contiguous clones selected from a chromosome 11 cosmid library. Analysis of these clones revealed that SAA1 and SAA2 are located 18 kb apart in opposite transcriptional orientations, while SAA4 lies 11 kb downstream from SAA2 in the same orientation: 3'(SAA1)5'-18 kb-5'(SAA2)3'-11 kb-5'(SAA4)3'. A fifth SAA clone isolated from this library was noncontiguous with the other four and contained the SAA3 pseudogene.
人类血清淀粉样蛋白A基因家族（SAA1、SAA2和SAA4）的三个表达基因已从11号染色体黏粒文库中选出的四个相邻克隆中分离出来。对这些克隆的分析表明，SAA1和SAA2以相反的转录方向相隔18 kb，而SAA4位于SAA2下游11 kb处，方向相同：3'（SAA1）5'-18 kb-5'（SAA2）3'-11 kb-5'（SAA4）3'。从该文库中分离出的第五个SAA克隆与其他四个不相邻，包含SAA3假基因。
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