Sellar G C, Whitehead A S
Department of Genetics, Trinity College, Dublin, Ireland.
Genomics. 1993 Jun;16(3):774-6. doi: 10.1006/geno.1993.1265.
The serum amyloid A proteins (SAAs) are heterogeneous differentially expressed apolipoproteins of M(r) 12-19 kDa. Four SAA loci have been described. Two of the loci (SAA1 and SAA2) encode acute-phase SAAs (A-SAAs), which exhibit a dramatic transient increase in serum concentration in response to inflammatory stimuli; a third locus (SAA3) defines a pseudogene; and a fourth locus (SAA4) encodes a constitutively expressed SAA (C-SAA). Using locus-specific polymerase chain reaction, we have definitively assigned all four well-characterized SAA loci, SAA1, -2, -3, and -4, to chromosome 11p. In addition, we have more fully characterized an ill-defined sequence previously misidentified by others as SAA4, which also maps to chromosome 11p and may represent a fifth SAA locus.
血清淀粉样蛋白A（SAA）是分子量为12 - 19 kDa的异质性差异表达载脂蛋白。已描述了四个SAA基因座。其中两个基因座（SAA1和SAA2）编码急性期SAA（A - SAA），其血清浓度在炎症刺激下会急剧短暂升高；第三个基因座（SAA3）是一个假基因；第四个基因座（SAA4）编码组成型表达的SAA（C - SAA）。利用基因座特异性聚合酶链反应，我们已明确将所有四个特征明确的SAA基因座SAA1、-2、-3和-4定位于11号染色体短臂。此外，我们对一个先前被他人误鉴定为SAA4的不明确序列进行了更全面的表征，该序列也定位于11号染色体短臂，可能代表第五个SAA基因座。
