人类感染结核分枝杆菌时的T细胞细胞因子反应
T-cell cytokine responses in human infection with Mycobacterium tuberculosis.
作者信息
Zhang M, Lin Y, Iyer D V, Gong J, Abrams J S, Barnes P F
机构信息
Department of Medicine, University of Southern California School of Medicine, Los Angeles 90033, USA.
出版信息
Infect Immun. 1995 Aug;63(8):3231-4. doi: 10.1128/iai.63.8.3231-3234.1995.
Abstract
Compared with healthy tuberculin reactors, Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells from tuberculosis patients had diminished production and mRNA expression of the Th1 cytokines gamma interferon and interleukin 2 (IL-2), with no change in production and mRNA expression for the Th2 cytokines IL-4, IL-10, and IL-13. These results were confirmed by evaluation of T cells and CD4+ cells. At the level of systemic T cells, development of tuberculosis is associated with diminished Th1 but not enhanced Th2 responses.
摘要
与健康的结核菌素反应者相比，来自结核病患者的经结核分枝杆菌刺激的外周血单个核细胞产生的Th1细胞因子γ干扰素和白细胞介素2（IL-2）减少，且mRNA表达降低，而Th2细胞因子IL-4、IL-10和IL-13的产生及mRNA表达没有变化。通过对T细胞和CD4+细胞的评估证实了这些结果。在全身T细胞水平上，结核病的发生与Th1反应减弱有关，而非Th2反应增强。
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