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Production of the new antibiotic tetrahydrokalafungin by transformants of the kalafungin producer Streptomyces tanashiensis.

作者信息

Kakinuma S, Ikeda H, Takada Y, Tanaka H, Hopwood D A, Omura S

机构信息

School of Pharmaceutical Sciences, Kitasato University, Kitasato Institute, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1995 Jun;48(6):484-7. doi: 10.7164/antibiotics.48.484.

DOI:10.7164/antibiotics.48.484
PMID:7622434
Abstract

The new antibiotic tetrahydrokalafungin was produced by the transformants of kalafungin producing S. tanashiensis and kalafungin-nonproducing mutants carrying the recombinant plasmid pKU523. This plasmid consists of pKU501 (J. Antibiotics 44: 995 approximately 1005, 1991) which contains the gene cluster for kalafungin biosynthesis, and additional 5 kb stability region of SCP2*.

摘要

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引用本文的文献

1
Accumulation of a bioactive benzoisochromanequinone compound kalafungin by a wild type antitumor-medermycin-producing streptomycete strain.野生型抗肿瘤美登霉素产生链霉菌菌株积累生物活性苯并异色满醌化合物卡拉芬净。
PLoS One. 2015 Feb 19;10(2):e0117690. doi: 10.1371/journal.pone.0117690. eCollection 2015.