Ferbas J, Kaplan A H, Hausner M A, Hultin L E, Matud J L, Liu Z, Panicali D L, Nerng-Ho H, Detels R, Giorgi J V
Department of Medicine, School of Medicine, University of California at Los Angeles, USA.
J Infect Dis. 1995 Aug;172(2):329-39. doi: 10.1093/infdis/172.2.329.
Persons infected with human immunodeficiency virus (HIV) for > 8 years were studied to delineate virologic and immunologic attributes of long-term survival. Whereas those with 300-700 CD4+ cells/microL often had circulating cytotoxic T lymphocytes (CTL) against HIV antigens, those with > 1000 CD4+ cells/microL did not. The subjects with > 1000 CD4+ cells/microL had low virus burden, low levels of Gag-specific CTL precursors, and minimal CD8+ cell activation. Overall, elevated levels of CD8+ cells, CD38 antigen expression on CD8+ cells, and anti-HIV functions were correlated with increased virus burden, provirus load, and HIV plasma RNA levels. A factor that suppressed HIV replication was spontaneously secreted from CD8+ cells of most subjects but not from those with high CD4+ cell counts. CD8+ cell activities, therefore, may reflect chronic viral stimulation of the immune system. Long-term survivors with high levels of CD4+ cells maintained control of viral replication but lacked the CD8+ cell activities.
对感染人类免疫缺陷病毒（HIV）超过8年的患者进行了研究，以描绘长期存活者的病毒学和免疫学特征。CD4 + 细胞计数为300 - 700个/微升的患者通常具有针对HIV抗原的循环细胞毒性T淋巴细胞（CTL），而CD4 + 细胞计数超过1000个/微升的患者则没有。CD4 + 细胞计数超过1000个/微升的受试者病毒载量低，Gag特异性CTL前体水平低，CD8 + 细胞活化程度最小。总体而言，CD8 + 细胞水平升高、CD8 + 细胞上CD38抗原表达以及抗HIV功能与病毒载量增加、前病毒负荷和HIV血浆RNA水平升高相关。大多数受试者的CD8 + 细胞可自发分泌一种抑制HIV复制的因子，而CD4 + 细胞计数高的受试者则不能。因此，CD8 + 细胞活性可能反映了免疫系统的慢性病毒刺激。CD4 + 细胞水平高的长期存活者能够控制病毒复制，但缺乏CD8 + 细胞活性。
