Sadeghi H M, Weiss L, Kazatchkine M D, Haeffner-Cavaillon N
Department of Immunology, INSERM U430, Hôpital Broussais, Paris, France.
J Infect Dis. 1995 Aug;172(2):547-50. doi: 10.1093/infdis/172.2.547.
Interleukin (IL)-1 is constitutively produced by monocytes of human immunodeficiency virus (HIV)-seropositive persons. The changes in the production of IL-1 by monocytes of 24 HIV-infected patients were investigated during the course of 8 months of antiretroviral therapy. At month 8, the amounts of biologically active IL-1 and IL-1 alpha and -beta proteins produced by freshly obtained monocytes and by monocytes cultured for 24 h in the absence of lipopolysaccharide (LPS) decreased significantly compared with pretreatment values or decreased below the limits of detection in the assays. Antiretroviral therapy also resulted in enhanced secretion of IL-1 receptor antagonist (IL-1Ra) by LPS-stimulated patients' monocytes. The reduction in the constitutive production of IL-1 and the increased ability of stimulated cells to produce IL-1Ra associated with antiretroviral therapy may also be of importance in reducing a major pathway of amplification of viral replication in infected monocytes and lymphocytes.
白细胞介素（IL）-1由人类免疫缺陷病毒（HIV）血清反应阳性者的单核细胞组成性产生。在24名HIV感染患者接受抗逆转录病毒治疗的8个月过程中，研究了其单核细胞产生IL-1的变化。在第8个月时，与治疗前的值相比，新鲜获取的单核细胞以及在无脂多糖（LPS）条件下培养24小时的单核细胞产生的生物活性IL-1以及IL-1α和-β蛋白的量显著减少，或降至检测限以下。抗逆转录病毒治疗还导致LPS刺激的患者单核细胞分泌IL-1受体拮抗剂（IL-1Ra）增加。与抗逆转录病毒治疗相关的IL-1组成性产生的减少以及刺激细胞产生IL-1Ra能力的增加，在减少感染的单核细胞和淋巴细胞中病毒复制放大的主要途径方面可能也很重要。
