一种来自海漆的新型佛波酯。

A novel phorbol ester from Excoecaria agallocha.

作者信息

Erickson K L, Beutler J A, Cardellina J H, McMahon J B, Newman D J, Boyd M R

机构信息

Laboratory of Drug Discovery Research and Development, National Cancer Institute, NCI-FCRDC, Maryland 21702-1201, USA.

出版信息

J Nat Prod. 1995 May;58(5):769-72. doi: 10.1021/np50119a020.

DOI:10.1021/np50119a020

PMID:7623051

Abstract

The novel phorbol ester 12-deoxyphorbol 13-(3E,5E-decadienoate) [1] was isolated as the anti-HIV principle of Excoecaria agallocha leaves and stems collected in northwest Australia. The structure was determined by spectral means. Compound 1 was also a potent displacer of [3H]-phorbol dibutyrate from rat brain membranes.

摘要

新型佛波酯12-脱氧佛波醇13-(3E,5E-癸二烯酸酯)[1]是从澳大利亚西北部采集的海漆属植物的叶和茎中分离得到的抗HIV活性成分。其结构通过光谱手段确定。化合物1也是[3H]-佛波醇二丁酸酯从大鼠脑膜上的有效置换剂。