Anti-AIDS agents, 9. Suberosol, a new C31 lanostane-type triterpene and anti-HIV principle from Polyalthia suberosa.
作者信息
Li H Y, Sun N J, Kashiwada Y, Sun L, Snider J V, Cosentino L M, Lee K H
机构信息
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
出版信息
J Nat Prod. 1993 Jul;56(7):1130-3. doi: 10.1021/np50097a017.
PMID:8377018
Abstract
A new C31 lanostane-type triterpene, assigned the trivial name suberosol [1], has been isolated from Polyalthia suberosa as an anti-HIV principle. The structure has been characterized as 24-methylenelanost-7,9(11)-diene-3 beta, 15 alpha-diol (suberosol) [1], based on spectroscopic evidence. Compound 1 was found to show anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 3 micrograms/ml.
摘要
Zotero 插件