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Anti-AIDS agents, 9. Suberosol, a new C31 lanostane-type triterpene and anti-HIV principle from Polyalthia suberosa.

作者信息

Li H Y, Sun N J, Kashiwada Y, Sun L, Snider J V, Cosentino L M, Lee K H

机构信息

Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599.

出版信息

J Nat Prod. 1993 Jul;56(7):1130-3. doi: 10.1021/np50097a017.

DOI:10.1021/np50097a017
PMID:8377018
Abstract

A new C31 lanostane-type triterpene, assigned the trivial name suberosol [1], has been isolated from Polyalthia suberosa as an anti-HIV principle. The structure has been characterized as 24-methylenelanost-7,9(11)-diene-3 beta, 15 alpha-diol (suberosol) [1], based on spectroscopic evidence. Compound 1 was found to show anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 3 micrograms/ml.

摘要

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