Cooper R D
Army Malaria Research Unit, Liverpool Military Area, NSW, Australia.
J Parasitol. 1995 Aug;81(4):640-1.
Attempts were made to infect splenectomized Guyanan Saimiri sciureus monkeys with the following Papua New Guinean strains of Plasmodium vivax: AMRU-1, a chloroquine-resistant strain; and AMRU-2, a chloroquine-sensitive strain. Inoculation of 7 monkeys with the AMRU-1 strain, 4 using blood-stage parasites and 3 using sporozoites, all failed to produce infections. Inoculation of 4 monkeys with the AMRU-2 strain, 3 using blood-stage parasites and 1 using sporozoites, were all successful in establishing infections. The results suggest that Guyanan Saimiri are refractory to infection with the AMRU-1 strain. If refractoriness occurs in other species and subspecies of Saimiri monkeys, then studies on the AMRU-1 strain of P. vivax may be restricted to work using Aotus monkeys.
AMRU - 1，一种耐氯喹菌株；以及AMRU - 2，一种氯喹敏感菌株。用AMRU - 1菌株接种7只猴子，4只使用血期寄生虫接种，3只使用子孢子接种，均未成功感染。用AMRU - 2菌株接种4只猴子，3只使用血期寄生虫接种，1只使用子孢子接种，均成功建立感染。结果表明，圭亚那松鼠猴对AMRU - 1菌株的感染具有抗性。如果其他种类和亚种的松鼠猴也存在抗性，那么对间日疟原虫AMRU - 1菌株的研究可能会局限于使用夜猴进行的工作。
