Collins W E, Sattabongkot J, Wirtz R A, Skinner J C, Broderson J R, Millet P G, Morris C L, Richardson B B, Sullivan J, Filipski V K
Division of Parasitic Diseases, Centers for Disease Control, Atlanta, Georgia 30333.
J Parasitol. 1992 Jun;78(3):485-91.
A strain of Plasmodium vivax from Thailand with a polymorphic repeat unit of the circumsporozoite protein was established in Saimiri sciureus boliviensis and 3 species of Aotus monkeys. All 11 attempts to transmit infection via sporozoite inoculation, 4 times to splenectomized S. sciureus boliviensis, 2 times to splenectomized Aotus nancymai, and 5 times to intact Saimiri monkeys, were successful. Anopheles freeborni, Anopheles stephensi, Anopheles dirus, and Anopheles gambiae mosquitoes were infected by feeding on parasitemic blood from a chimpanzee and an Aotus azarae boliviensis monkey. Our results indicate that this strain may be useful in antisporozoite vaccine trials.
一株来自泰国的具有多态性环子孢子蛋白重复单元的间日疟原虫在玻利维亚松鼠猴和3种夜猴中建立了感染。通过子孢子接种传播感染的11次尝试全部成功，其中4次接种到脾切除的玻利维亚松鼠猴，2次接种到脾切除的南氏夜猴，5次接种到完整的松鼠猴。通过吸食感染黑猩猩和玻利维亚阿扎拉夜猴的含虫血，使弗里伯恩按蚊、斯氏按蚊、大劣按蚊和冈比亚按蚊感染。我们的结果表明，该菌株可能有助于抗子孢子疫苗试验。
