Kosten T R, Rayford B S
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
J Subst Abuse Treat. 1995 Mar-Apr;12(2):111-6. doi: 10.1016/0740-5472(94)00069-4.
In a recent randomized clinical trial using buprenorphine (2 and 6 mg) and methadone (35 and 65 mg), we compared low-level opiate withdrawal symptoms among Whites (n = 84), Hispanics (n = 20), and African Americans (n = 21). During the first 2 months of opiate stabilization, persistent low-level opiate withdrawal symptoms were significantly lower in African-Americans and Hispanics than in the white patients. As expected pharmacologically, this relative underreporting of low-level withdrawal by minority patients was greater for the low opiate doses (buprenorphine 2 mg and methadone 35 mg). This underreporting may reflect sociocultural as well as biological differences, because subjective, but not objective, withdrawal symptoms showed this ethnic difference.
在最近一项使用丁丙诺啡（2毫克和6毫克）和美沙酮（35毫克和65毫克）的随机临床试验中，我们比较了白人（n = 84）、西班牙裔（n = 20）和非裔美国人（n = 21）的低水平阿片类药物戒断症状。在阿片类药物稳定治疗的前两个月，非裔美国人和西班牙裔患者持续的低水平阿片类药物戒断症状明显低于白人患者。从药理学角度预期，少数族裔患者对低水平戒断症状的这种相对报告不足在低阿片剂量（丁丙诺啡2毫克和美沙酮35毫克）时更为明显。这种报告不足可能反映了社会文化以及生物学差异，因为主观而非客观的戒断症状显示出这种种族差异。
