日本散发性克雅氏病患者载脂蛋白E的等位基因变异

Allelic variation of apolipoprotein E in Japanese sporadic Creutzfeldt-Jakob disease patients.

作者信息

Nakagawa Y, Kitamoto T, Furukawa H, Ogomori K, Tateishi J

机构信息

Department of Neuropathology, Kyushu University, Fukuoka, Japan.

出版信息

Neurosci Lett. 1995 Mar 10;187(3):209-11. doi: 10.1016/0304-3940(95)11366-5.

DOI:10.1016/0304-3940(95)11366-5

PMID:7624027

Abstract

We analyzed apolipoprotein E (apo E) genotypes in 53 Japanese sporadic Creutzfeldt-Jakob disease (CJD) patients and 100 normal controls using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. The apo E allelic frequencies in Japanese sporadic CJD patients and our control population were as follows: epsilon 2, 6.6% versus 7.5%; epsilon 3, 82.1% versus 81.5%; epsilon 4, 11.3% versus 11.0%. The mean ages at onset in Japanese sporadic CJD patients were as follows: epsilon 3/epsilon 3, 63.8 years; epsilon 3/epsilon 4, 66.3 years; epsilon 2/epsilon 3, 68.6 years. These results indicate that there is no association between apo E genotype and sporadic CJD in Japan.

摘要

我们使用聚合酶链反应（PCR）和限制性片段长度多态性（RFLP）方法，分析了53例日本散发性克雅氏病（CJD）患者和100名正常对照者的载脂蛋白E（apo E）基因型。日本散发性CJD患者和我们的对照人群中apo E等位基因频率如下：ε2，6.6% 对7.5%；ε3，82.1% 对81.5%；ε4，11.3% 对11.0%。日本散发性CJD患者的平均发病年龄如下：ε3/ε3，63.8岁；ε3/ε4，66.3岁；ε2/ε3，68.6岁。这些结果表明，在日本，apo E基因型与散发性CJD之间不存在关联。