Liebermann D A, Hoffman B, Steinman R A
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Oncogene. 1995 Jul 6;11(1):199-210.
Cell homeostasis is regulated by a balance between proliferation, growth arrest and programmed cell death (apoptosis). Until recently, studies on oncogenesis have focused on the regulation of cell proliferation. The recognition that negative growth control, including growth arrest and programmed cell death, must be understood to comprehend how appropriate cell numbers are maintained and how alterations in any part of the equation can contribute to malignancy has led to a burst of work in this field. This review focuses on what has been learned about distinct settings of negative growth control, analyzing p53-dependent and independent pathways of growth arrest and apoptosis either coupled or uncoupled from differentiation, with an emphasis on the use of hematopoietic cells. The importance of understanding the molecular biology of apoptotic and growth arrest pathways in cancer therapy, and future directions to study negative growth control are addressed as well.
细胞稳态由增殖、生长停滞和程序性细胞死亡（凋亡）之间的平衡来调节。直到最近，肿瘤发生的研究一直集中在细胞增殖的调控上。认识到必须理解包括生长停滞和程序性细胞死亡在内的负性生长控制，才能理解如何维持适当的细胞数量，以及该平衡中任何一部分的改变如何导致恶性肿瘤，这引发了该领域的大量研究工作。本综述重点关注关于负性生长控制不同情况的已知内容，分析与分化相关或无关的、依赖p53和不依赖p53的生长停滞及凋亡途径，重点是造血细胞的应用。同时也阐述了理解癌症治疗中凋亡和生长停滞途径的分子生物学的重要性以及研究负性生长控制的未来方向。
