Graña X, Reddy E P
Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Oncogene. 1995 Jul 20;11(2):211-9.
All eukaryotic cells possess similar mechanisms to regulate the progression of the cell cycle. However, higher eukaryotes have evolved to respond to a large array of positive and negative signals with an intracellular or extracellular origin. These signals are eventually integrated by a conserved protein engine consisting of holoenzymes with kinase activity, which trigger crucial transitions during the cell cycle. In this review, the mechanisms by which the mammalian cell cycle engine integrates intracellular and extracellular signals of different nature are discussed.
所有真核细胞都拥有相似的机制来调节细胞周期的进程。然而，高等真核生物已经进化到能够对大量源自细胞内或细胞外的正负信号做出反应。这些信号最终由一个由具有激酶活性的全酶组成的保守蛋白质引擎整合，该引擎在细胞周期中触发关键转变。在这篇综述中，将讨论哺乳动物细胞周期引擎整合不同性质的细胞内和细胞外信号的机制。
