Rackovsky S
Department of Biomathematical Sciences, Mt. Sinai School of Medicine, New York, NY 10029-6574, USA.
Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6861-3. doi: 10.1073/pnas.92.15.6861.
The existence of a code relating the set of possible sequences at a given position in a protein backbone to the local structure at that location is investigated. It is shown that only 73% of 4-C alpha structure fragments in a sample of 114 protein structures exhibit a preference for a particular set of sequences. The remaining structures can accommodate essentially any sequence. The structures that encode specific sequence distributions include the classical "secondary" structures, with the notable exception of planar (beta) bends. It is suggested that this has implications as to the mechanism of folding in proteins with extensive sheet/barrel structure. The possible role of structures that do not encode specific sequences as mutation hot spots is noted.
研究了在蛋白质主链给定位置上，将可能的序列集与该位置局部结构相关联的一种编码的存在情况。结果表明，在114个蛋白质结构的样本中，4-Cα结构片段仅有73%表现出对特定序列集的偏好。其余结构基本上可以容纳任何序列。编码特定序列分布的结构包括经典的“二级”结构，但平面（β）转角是个明显的例外。这表明这对于具有广泛片层/桶状结构的蛋白质的折叠机制具有启示意义。文中还提到了不编码特定序列的结构作为突变热点的可能作用。
