van Gelderen P, Ramsey N F, Liu G, Duyn J H, Frank J A, Weinberger D R, Moonen C T
National Institutes of Health In Vivo Nuclear Magnetic Resonance Research Center, Biomedical Engineering and Instrumentation Program, Bethesda, MD 20892, USA.
Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6906-10. doi: 10.1073/pnas.92.15.6906.
Functional magnetic resonance imaging (fMRI) is a tool for mapping brain function that utilizes neuronal activity-induced changes in blood oxygenation. An efficient three-dimensional fMRI method is presented for imaging brain activity on conventional, widely available, 1.5-T scanners, without additional hardware. This approach uses large magnetic susceptibility weighting based on the echo-shifting principle combined with multiple gradient echoes per excitation. Motor stimulation, induced by self-paced finger tapping, reliably produced significant signal increase in the hand region of the contralateral primary motor cortex in every subject tested.
功能磁共振成像（fMRI）是一种用于绘制脑功能的工具，它利用神经元活动引起的血液氧合变化。本文提出了一种高效的三维fMRI方法，用于在传统的、广泛使用的1.5-T扫描仪上对脑活动进行成像，无需额外的硬件。该方法基于回波移位原理，结合每次激发的多个梯度回波，使用大的磁敏感性加权。在每个测试对象中，由自主节奏的手指敲击诱导的运动刺激在对侧初级运动皮层的手部区域可靠地产生了显著的信号增加。
