Jackman S V, Thompson J T
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA.
Retina. 1995;15(2):160-6. doi: 10.1097/00006982-199515020-00013.
Air travel is known to be potentially hazardous for patients with intraocular gas bubbles, and the external pressure changes associated with hyperbaric oxygen therapy and scuba diving could be similarly dangerous.
Rabbits with a perfluoropropane/air gas mixture filling approximately 60% of the vitreous cavity of the right eye were exposed to 3 different hyperbaric pressure profiles to an equivalent depth of 33 feet. The first group were a control group and were not exposed to hyperbaric pressures. The second group remained at an equivalent depth of 33 feet for 30 minutes, and the third group remained at 33 feet for 1 minute. Both groups ascended to normal atmospheric pressure at a rate of 1 foot per minute. The fourth group remained at 33 feet for 1 minute and then ascended at a rate of 0.2 feet per minute.
In all eyes with an intraocular gas bubble, intraocular pressure dropped to zero when the atmospheric pressure was increased, and rose to more than 50 mmHg when the atmospheric pressure was returned to normal. Pressures in excess of 50 mmHg were sustained for 10 minutes or longer in each rabbit exposed to one of the hyperbaric profiles. No significant intraocular pressure changes were observed in eyes without an intraocular gas bubble or eyes not exposed to hyperbaric pressure.
Marked elevation in intraocular pressure occurs as a result of hyperbaric exposure in eyes with an intraocular gas bubble. Hyperbaric exposure is therefore not advisable for patients with intraocular gas bubbles.
众所周知，航空旅行对眼内有气泡的患者有潜在危害，与高压氧治疗和水肺潜水相关的外界压力变化可能同样危险。
右眼玻璃体腔约60%填充全氟丙烷/空气混合气体的兔子，暴露于3种不同的高压压力曲线下，相当于33英尺的深度。第一组为对照组，未暴露于高压环境。第二组在相当于33英尺的深度停留30分钟，第三组在33英尺处停留1分钟。两组均以每分钟1英尺的速度升至正常大气压。第四组在33英尺处停留1分钟，然后以每分钟0.2英尺的速度上升。
在所有眼内有气泡的眼睛中，当大气压升高时眼压降至零，当大气压恢复正常时眼压升至50 mmHg以上。暴露于其中一种高压曲线下的每只兔子，眼压超过50 mmHg的情况持续了10分钟或更长时间。在没有眼内气泡或未暴露于高压环境的眼睛中，未观察到明显的眼压变化。
眼内有气泡的眼睛在高压暴露后眼压会显著升高。因此，眼内有气泡的患者不宜进行高压暴露。
