Kuwahira I, Moue Y, Ohta Y, Gonzalez N C
Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan.
Respir Physiol. 1995 May;100(2):151-7. doi: 10.1016/0034-5687(94)00131-i.
The effect of hypoxia on pulmonary blood flow (PBF) distribution were studied in 11 conscious resting rats. Microspheres were infused into the inferior vena cava during normoxia (Nx), acute normobaric hypoxia (AHx, 10% O2, 30 min), and 30 min after removal of hypoxia (post-hypoxia, PHx). The lungs were cut into 28 samples, and relative scatter of specific PBF was calculated as (sample activity/sample dry weight)/(total activity/total lung dry weight). Changes in pulmonary arterial pressure (PAP) during AHx were determined in five additional rats. During Nx, PBF was distributed preferentially to the hilar, central regions, rather than to the periphery. AHx resulted in a decrease in PaO2 from 85.1 +/- 0.9 to 37.8 +/- 1.2 Torr (mean +/- SE). Mean PAP increased significantly from 14.9 +/- 0.6 in Nx to 21.2 +/- 1.0 Torr in AHx (mean +/- SE). However, PBF distribution remained unchanged. PHx restored arterial blood gases and PAP to control levels without changing PBF distribution. The results indicate that conscious resting rats do not demonstrate changes in PBF distribution during AHx.
在11只清醒静息大鼠中研究了缺氧对肺血流（PBF）分布的影响。在常氧（Nx）、急性常压缺氧（AHx，10%氧气，30分钟）以及缺氧去除后30分钟（缺氧后，PHx）期间，将微球注入下腔静脉。将肺切成28个样本，并计算比PBF的相对离散度，计算方法为（样本活性/样本干重）/（总活性/全肺干重）。在另外5只大鼠中测定AHx期间肺动脉压（PAP）的变化。在Nx期间，PBF优先分布于肺门、中央区域，而非外周区域。AHx导致动脉血氧分压（PaO2）从85.1±0.9 Torr降至37.8±1.2 Torr（平均值±标准误）。平均PAP从Nx时的14.9±0.6 Torr显著增加至AHx时的21.2±1.0 Torr（平均值±标准误）。然而，PBF分布保持不变。PHx使动脉血气和PAP恢复至对照水平，而不改变PBF分布。结果表明，清醒静息大鼠在AHx期间未表现出PBF分布的变化。
