Kuwahira I, Moue Y, Ohta Y, Gonzalez N C
Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan.
Respir Physiol. 1996 Jul;104(2-3):205-12. doi: 10.1016/0034-5687(96)00020-5.
Pulmonary blood flow (PBF) distribution was studied in 15 chronically hypoxic rats (3 weeks, 10% O2 in N2) breathing 10% O2 (chronic hypoxia, CHx) and after 30 min of breathing air (acute normoxia, ANx). Controls were 15 normoxic littermates (normoxia, Nx) breathing air. Nonradioactive microspheres were infused into the inferior vena cava in the conscious resting state. The lungs were cut into 28 samples, and relative scatter of specific PBF was calculated as (sample activity/sample dry weight)/(total activity/total lung dry weight). In Nx, PBF had a small but significant preferential distribution to the hilar, central regions, with lower blood flow to the peripheral regions (central-to-peripheral pattern). In CHx, however, there was no significant difference between blood flows to the central, middle and peripheral regions of the lung. ANx resulted in no change in PBF distribution. The results indicate that CHx attenuates the central-to-peripheral gradient of PBF distribution, probably due to vascular structural remodeling developed in CHx.
对15只慢性低氧大鼠（3周，氮气中10%氧气）在吸入10%氧气时（慢性低氧，CHx）以及吸入空气30分钟后（急性常氧，ANx）的肺血流（PBF）分布进行了研究。对照组为15只吸入空气的同窝常氧大鼠（常氧，Nx）。在清醒静息状态下将非放射性微球注入下腔静脉。将肺切成28个样本，并计算特定PBF的相对离散度，即（样本活性/样本干重）/（总活性/全肺干重）。在Nx组中，PBF在肺门、中央区域有小但显著的优先分布，外周区域血流较低（中央到外周模式）。然而，在CHx组中，肺中央、中间和外周区域的血流之间没有显著差异。ANx导致PBF分布无变化。结果表明，CHx减弱了PBF分布的中央到外周梯度，这可能是由于CHx中发生的血管结构重塑所致。
