Gwent S H, Wilson J F, Tsanaclis L M, Wicks J F
Department of Pharmacology and Therapeutics, University of Wales College of Medicine, Cardiff, U.K.
Ther Drug Monit. 1995 Apr;17(2):195-8. doi: 10.1097/00007691-199504000-00016.
The time course of appearance of cotinine in saliva and in daily collections of beard clippings was monitored by gas chromatography with mass spectrometry in six volunteers who were nonsmokers following a single 30-min buccal administration of nicotine as a chewing gum. Salivary cotinine concentrations reached a plateau after 1.5 h and were nondetectable (< 0.3 ng/ml) 24 h after drug administration. Cotinine was detected in extracts of sodium hydroxide digests of beard hair in all subjects on the third day after drug administration. Mean concentrations in beard peaked on day 5, and cotinine was not detected (< 0.03 ng/mg) after day 7. The data indicate the main route for cotinine incorporation into beard is during hair growth. Transfer into beard from sweat is of little importance. A role for transfer via sebum is equivocal.
通过气相色谱-质谱联用仪，对6名不吸烟的志愿者进行监测，这些志愿者单次经口腔给予30分钟的尼古丁口香糖后，检测其唾液和每日收集的胡须剪屑中可替宁的出现时间过程。唾液中可替宁浓度在1.5小时后达到平稳状态，给药后24小时检测不到（<0.3纳克/毫升）。给药后第三天，所有受试者的胡须毛发氢氧化钠消化提取物中均检测到可替宁。胡须中的平均浓度在第5天达到峰值，第7天后未检测到可替宁（<0.03纳克/毫克）。数据表明，可替宁掺入胡须的主要途径是在头发生长期间。通过汗液转移到胡须中的作用很小。通过皮脂转移的作用尚不明确。
