Verger J M, Grayon M, Zundel E, Lechopier P, Olivier-Bernardin V
Laboratoire de Pathologie Infectieuse et d'Immunologie, INRA, Nouzilly, France.
Vaccine. 1995 Feb;13(2):191-6. doi: 10.1016/0264-410x(95)93135-v.
The comparative efficacy of Brucella suis strain 2 (S2) and Brucella melitensis strain Rev. 1 (Rev. 1) live vaccines in protecting sheep against B. melitensis infection was evaluated by clinical and bacteriological examination of ewes vaccinated conjunctivally with a dose of 1 x 10(9) c.f.u. when 4 months old and then challenged with 5 x 10(7) c.f.u. of the B. melitensis virulent strain 53H38 (H38) at the middle of the first or second pregnancy following vaccination. Animals were considered to be protected when no abortion, no excretion of the challenge strain and no infection at slaughter occurred. The percentages of protection in Rev. 1-vaccinated groups challenged during either first (80%) or second (62%) pregnancy were significantly different (p < 0.001 and p < 0.05, respectively) compared with those of the relevant unvaccinated control groups. In contrast no significant difference in protection was found between the S2-vaccinated and control groups.
通过对4月龄时结膜接种剂量为1×10⁹ c.f.u.的母羊进行临床和细菌学检查，评估猪布鲁氏菌2型（S2）和羊布鲁氏菌Rev.1株（Rev.1）活疫苗在保护绵羊抵抗羊布鲁氏菌感染方面的相对效力。接种后，在首次或第二次妊娠中期，用5×10⁷ c.f.u.的羊布鲁氏菌强毒株53H38（H38）对母羊进行攻毒。当未发生流产、未排出攻毒株且屠宰时未发现感染时，动物被认为受到了保护。与相应的未接种疫苗对照组相比，在首次妊娠（80%）或第二次妊娠（62%）期间接受攻毒的Rev.1疫苗接种组的保护百分比有显著差异（分别为p < 0.001和p < 0.05）。相比之下，S2疫苗接种组和对照组之间在保护方面未发现显著差异。
