Alabi Z O, Thomas K D, Ogunbona O, Elegbe I A
Faculty of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
Afr J Med Med Sci. 1994 Jun;23(2):143-6.
Previous report on the estimation of plasma ascorbic acid levels in patients with chronic osteomyelitis indicated that the plasma ascorbic acid level is reduced in patients on antibiotics. The plasma study of the effects of anti-bacterial agents on plasma ascorbic acid in vitro, was carried out to substantiate the hypothesis than these agents lower plasma ascorbic acid levels. Increasing amounts of each of seven anti-bacterial agents: ampicillin, chloramphenicol, cefotaxime, gentamycin, benzyl and procaine penicillin combination (seclopen), co-trimoxazole, and streptomycin significantly (P < 0.01, r = -0.9587) reduced plasma vitamin C levels in vitro. There was moderate but insignificant reduction in plasma vitamin C levels with clindamycin (r = -0.799). The reduction of the plasma vitamin C levels observed in the presence of the eighth anti-bacterial agent, clindamycin, lacked significance (r = -0.799). The cause of this reduction of plasma vitamin C levels by anti-bacterial agents in vitro is not yet understood. A supplement of vitamin C may be required in patients on anti-bacterial agents.
先前关于慢性骨髓炎患者血浆抗坏血酸水平估计的报告表明，使用抗生素的患者血浆抗坏血酸水平会降低。为了证实抗菌药物会降低血浆抗坏血酸水平这一假设，进行了体外抗菌药物对血浆抗坏血酸影响的血浆研究。七种抗菌药物（氨苄西林、氯霉素、头孢噻肟、庆大霉素、苄星青霉素和普鲁卡因青霉素组合（双氯西林）、复方新诺明和链霉素）中的每一种用量增加时，均能显著（P < 0.01，r = -0.9587）降低体外血浆维生素C水平。克林霉素使血浆维生素C水平有中度但不显著的降低（r = -0.799）。在第八种抗菌药物克林霉素存在的情况下观察到的血浆维生素C水平降低缺乏统计学意义（r = -0.799）。体外抗菌药物降低血浆维生素C水平的原因尚不清楚。使用抗菌药物的患者可能需要补充维生素C。
