D-和L-相关立体化学的等轴双脱氧核苷的抗病毒活性。
Antiviral activities of isometric dideoxynucleosides of D- and L-related stereochemistry.
作者信息
Nair V, Jahnke T S
机构信息
Department of Chemistry, University of Iowa, Iowa City 52242, USA.
出版信息
Antimicrob Agents Chemother. 1995 May;39(5):1017-29. doi: 10.1128/AAC.39.5.1017.
Abstract
In summary, many isomeric analogs of ddNs of both D-related and L-related absolute stereochemistries have been synthesized and evaluated in vitro for their antiviral activities. A few of these compounds exhibit potent antiviral activity and, interestingly, belong to both the D and L families. The synthetic methodologies developed will allow accessibility to many more novel modified nucleosides. While some structure-activity relationships are emerging from this work, it is clear that these chiral isomeric nucleosides have opened a new chapter in the field of antiviral nucleosides.
摘要
总之，已经合成了许多具有D型和L型绝对立体化学的ddN的异构类似物，并在体外评估了它们的抗病毒活性。其中一些化合物表现出强大的抗病毒活性，有趣的是，它们分属于D族和L族。所开发的合成方法将有助于获得更多新型修饰核苷。虽然这项工作中出现了一些构效关系，但很明显，这些手性异构核苷在抗病毒核苷领域开启了新的篇章。
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