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维生素A疗法用于呼吸道合胞病毒感染婴儿的安全性和药代动力学

Safety and pharmacokinetics of vitamin A therapy for infants with respiratory syncytial virus infections.

作者信息

Neuzil K M, Gruber W C, Chytil F, Stahlman M T, Graham B S

机构信息

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

出版信息

Antimicrob Agents Chemother. 1995 May;39(5):1191-3. doi: 10.1128/AAC.39.5.1191.

DOI:10.1128/AAC.39.5.1191
PMID:7625814
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162709/
Abstract

Infants with respiratory syncytial virus infection have low serum vitamin A levels. We treated 21 respiratory syncytial virus-infected children with 12,500 to 25,000 IU of oral vitamin A. Vitamin A levels were normalized at 6 h, and none of the children experienced vitamin A toxicity or exacerbation of respiratory illness. Vitamin A treatment of previously healthy respiratory syncytial virus-infected infants at these doses is safe and well tolerated.

摘要

感染呼吸道合胞病毒的婴儿血清维生素A水平较低。我们对21名感染呼吸道合胞病毒的儿童给予12,500至25,000国际单位的口服维生素A进行治疗。维生素A水平在6小时时恢复正常,且没有儿童出现维生素A中毒或呼吸道疾病加重的情况。以这些剂量对先前健康的感染呼吸道合胞病毒的婴儿进行维生素A治疗是安全的,且耐受性良好。

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本文引用的文献

1
Serum vitamin A levels in respiratory syncytial virus infection.呼吸道合胞病毒感染时的血清维生素A水平
J Pediatr. 1994 Mar;124(3):433-6. doi: 10.1016/s0022-3476(94)70369-8.
2
Acute toxicity of vitamin A given with vaccines in infancy.婴儿期维生素A与疫苗同时使用的急性毒性。
Lancet. 1993 Aug 28;342(8870):526-7. doi: 10.1016/0140-6736(93)91648-6.
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Fluorometric determination of vitamin A in human blood and liver.
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Vitamin A supplements and mortality related to measles: a randomised clinical trial.维生素A补充剂与麻疹相关死亡率:一项随机临床试验。
Br Med J (Clin Res Ed). 1987 Jan 31;294(6567):294-6. doi: 10.1136/bmj.294.6567.294.
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A randomized, controlled trial of vitamin A in children with severe measles.一项针对重症麻疹患儿的维生素A随机对照试验。
N Engl J Med. 1990 Jul 19;323(3):160-4. doi: 10.1056/NEJM199007193230304.
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Plasma retinol-binding protein response to vitamin A administration in infants susceptible to bronchopulmonary dysplasia.血浆视黄醇结合蛋白对易患支气管肺发育不良婴儿给予维生素A的反应。
J Pediatr. 1990 Apr;116(4):607-14. doi: 10.1016/s0022-3476(05)81614-2.
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Vitamin A supplementation enhances specific IgG antibody levels and total lymphocyte numbers while improving morbidity in measles.
Pediatr Infect Dis J. 1992 Mar;11(3):203-9. doi: 10.1097/00006454-199203000-00006.
8
Tolerance of young infants to a single, large dose of vitamin A: a randomized community trial in Nepal.幼儿对大剂量单一维生素A的耐受性:尼泊尔的一项随机社区试验
Bull World Health Organ. 1992;70(6):733-9.
9
Simultaneous determination of alpha-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography.通过高压液相色谱法同时测定血浆或红细胞中的α-生育酚和视黄醇。
Am J Clin Nutr. 1979 Oct;32(10):2143-9. doi: 10.1093/ajcn/32.10.2143.