Graham D I, Behan P O, More I A
J Neurol Neurosurg Psychiatry. 1979 Jan;42(1):19-28. doi: 10.1136/jnnp.42.1.19.
The neuropathological findings in six patients who developed neurological signs after the onset of "septic shock" caused by Gram-negative septicaemia are described. The changes in the brains were characteristic of acute haemorrhagic leucoencephalitis, and there was evidence, particularly in the kidneys, of disseminated intravascular coagulation with tubular necrosis and, in some, appearances indistinguishable from membrano-proliferative glomerulonephritis. It is agreed that acute haemorrhagic leucoencephalitis is another manifestation of a generalised Shwartzman reaction, and it is suggested that activation of complement is the final common pathway that produces tissue damage in the brain and kidney.
本文描述了6例因革兰氏阴性菌败血症导致“感染性休克”后出现神经症状患者的神经病理学发现。脑部变化具有急性出血性白质脑炎的特征，并且有证据表明，特别是在肾脏中，存在弥散性血管内凝血伴肾小管坏死，部分患者的表现与膜增生性肾小球肾炎难以区分。大家一致认为，急性出血性白质脑炎是全身性施瓦茨曼反应的另一种表现形式，有人提出补体激活是导致脑和肾组织损伤的最终共同途径。
