厚朴酚通过一种精子头部固定方法保护人类精子活力免受脂质过氧化影响。

Magnolol protects human sperm motility against lipid peroxidation: a sperm head fixation method.

作者信息

Lin M H, Chao H T, Hong C Y

机构信息

Institute of Traditional Medicine, National Yang-Ming University Medical College, Taipei, Taiwan, ROC.

出版信息

Arch Androl. 1995 May-Jun;34(3):151-6. doi: 10.3109/01485019508987843.

DOI:10.3109/01485019508987843

PMID:7625878

Abstract

It was previously reported that magnolol, isolated from the Chinese medicinal herb Magnolia officinalis, had a potent inhibitory activity on lipid peroxidation. Since sperm motility could be suppressed by lipid peroxidation, this study examines the protective effect of magnolol on lipid peroxidation-suppressed sperm motility. FeSO4 was used to induced lipid peroxidation and sperm motility was expressed as tail beat frequency (TBF) measured with a sperm head fixation method. Magnolol at 10(-9) to 10(-7) M significantly reversed the FeSO4-suppressed TBF. Magnolol significantly inhibited the generation of malondialdehyde (MDA), the end product of lipid peroxidation, in sperm. Magnolol protected sperm motility by inhibiting lipid peroxidation in sperm.

摘要

先前有报道称，从中药材厚朴中分离出的厚朴酚对脂质过氧化具有强大的抑制活性。由于精子活力会受到脂质过氧化的抑制，本研究考察了厚朴酚对脂质过氧化抑制的精子活力的保护作用。使用硫酸亚铁诱导脂质过氧化，精子活力以采用精子头部固定法测量的尾鞭频率（TBF）表示。10⁻⁹至10⁻⁷M的厚朴酚可显著逆转硫酸亚铁抑制的TBF。厚朴酚可显著抑制精子中脂质过氧化终产物丙二醛（MDA）的生成。厚朴酚通过抑制精子中的脂质过氧化来保护精子活力。