Lin M H, Chao H T, Hong C Y
Institute of Traditional Medicine, National Yang-Ming University Medical College, Taipei, Taiwan, ROC.
Arch Androl. 1995 May-Jun;34(3):151-6. doi: 10.3109/01485019508987843.
It was previously reported that magnolol, isolated from the Chinese medicinal herb Magnolia officinalis, had a potent inhibitory activity on lipid peroxidation. Since sperm motility could be suppressed by lipid peroxidation, this study examines the protective effect of magnolol on lipid peroxidation-suppressed sperm motility. FeSO4 was used to induced lipid peroxidation and sperm motility was expressed as tail beat frequency (TBF) measured with a sperm head fixation method. Magnolol at 10(-9) to 10(-7) M significantly reversed the FeSO4-suppressed TBF. Magnolol significantly inhibited the generation of malondialdehyde (MDA), the end product of lipid peroxidation, in sperm. Magnolol protected sperm motility by inhibiting lipid peroxidation in sperm.
先前有报道称，从中药材厚朴中分离出的厚朴酚对脂质过氧化具有强大的抑制活性。由于精子活力会受到脂质过氧化的抑制，本研究考察了厚朴酚对脂质过氧化抑制的精子活力的保护作用。使用硫酸亚铁诱导脂质过氧化，精子活力以采用精子头部固定法测量的尾鞭频率（TBF）表示。10⁻⁹至10⁻⁷M的厚朴酚可显著逆转硫酸亚铁抑制的TBF。厚朴酚可显著抑制精子中脂质过氧化终产物丙二醛（MDA）的生成。厚朴酚通过抑制精子中的脂质过氧化来保护精子活力。
