人肠道二胺氧化酶在组胺和/或腐胺氧化中的重要性。
The importance of human intestinal diamine oxidase in the oxidation of histamine and/or putrescine.
作者信息
Biegański T, Kusche J, Feussner K D, Hesterberg R, Richter H, Lorenz W
出版信息
Arch Immunol Ther Exp (Warsz). 1980;28(6):901-6.
Histamine, naturally methylated histamine and putrescine are good substrates for human intestinal diamine oxidase, N-Methyl-N-formylhydrazine, the constituent of the mashroom poison-gyromitrin is an inhibitor of human intestinal diamine oxidase. Burimamide inhibits more effectively mammalian intestinal diamine oxidases than pea seedling diamine oxidase, beta-aminopropionitrile is a better inhibitor of pea seedling enzyme than mammalian diamine oxidases. This inhibitory differences might be related to preference in histamine or putrescine oxidizing activity of these enzymes.
组胺、天然甲基化组胺和腐胺是人体肠道二胺氧化酶的良好底物，蘑菇毒素-鹿花菌素的成分N-甲基-N-甲酰肼是人体肠道二胺氧化酶的抑制剂。布立马胺对哺乳动物肠道二胺氧化酶的抑制作用比对豌豆幼苗二胺氧化酶的抑制作用更有效，β-氨基丙腈对豌豆幼苗酶的抑制作用比对哺乳动物二胺氧化酶的抑制作用更好。这种抑制差异可能与这些酶在组胺或腐胺氧化活性方面的偏好有关。
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