1,25-二羟维生素D3的免疫调节作用
Immunomodulatory actions of 1,25-dihydroxyvitamin D3.
作者信息
Lemire J M
机构信息
Department of Pediatrics, University of California, San Diego, La Jolla 92093-0609, USA.
出版信息
J Steroid Biochem Mol Biol. 1995 Jun;53(1-6):599-602. doi: 10.1016/0960-0760(95)00106-a.
The sterol, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), has immunosuppressive activity. The hormone inhibits the production of lymphokines (IL-2, IFN-gamma) and monocyte-derived cytokine (IL-12) leading to inhibition of helper T cell subset type 1 (Th1). When given in vivo, the hormone prevents the development of spontaneous and induced models of autoimmunity. Analogs of 1,25(OH)2D3, with reduced hypercalcemic effects, display an enhanced activity in autoimmunity compared to the sterol and prolong graft survival in experimental transplantation. This paper reviews our understanding of the cellular actions of the hormone and the therapeutic application of 1,25(OH)2D3 and analogs in autoimmunity and transplantation.
固醇1,25 - 二羟基维生素D3（1,25(OH)2D3）具有免疫抑制活性。该激素可抑制淋巴因子（白细胞介素-2、干扰素-γ）和单核细胞衍生细胞因子（白细胞介素-12）的产生，从而抑制1型辅助性T细胞亚群（Th1）。在体内给予该激素时，它可预防自身免疫的自发模型和诱导模型的发展。与该固醇相比，具有降低高钙血症作用的1,25(OH)2D3类似物在自身免疫中表现出增强的活性，并可延长实验性移植中的移植物存活时间。本文综述了我们对该激素细胞作用的理解以及1,25(OH)2D3及其类似物在自身免疫和移植中的治疗应用。
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