Ahmed H, Yukubu A M, Hendrickse R G
Department of Paediatrics, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.
West Afr J Med. 1995 Jan-Mar;14(1):15-23.
Of the 587 neonates born in ABUTH, Zaria, Nigeria and successfully followed up, 99 were clinically jaundiced (16.9%). Of these, only 38 (38%) had significant hyperbilirubinaemia (serum bilirubin above 170 umol/L). During the same period, 279 neonates were admitted through Emergency Paediatric Unit (EPU) of whom 70 (25%) were jaundiced and 64 (95%) of them had serum bilirubin above 170 umol/L. Jaundice was more severe and the incidence of kernicterus higher in babies born outside the hospital than in those born in hospital and periodically followed up. The incidence of kernicterus was 20.3% and 2.6% respectively. The pattern of aetiological factors was similar in the two groups of jaundiced neonates. Septicaemia (50%) and G6PD deficiency (40%) were the major aetiological factors. Exposure to traditional herbal medications, oxytocin induced/augmented labour, cephalhaematoma and tribal incidences did not play statistically significant roles. Jaundice due to Rh-incompatibility was not encountered. Results of this double prospective study were compared with the previous findings in this and other centres in Nigeria.
在尼日利亚扎里亚市阿布贾大学教学医院出生并成功接受随访的587名新生儿中，99名出现临床黄疸（16.9%）。其中，只有38名（38%）患有显著高胆红素血症（血清胆红素高于170μmol/L）。同一时期，279名新生儿通过儿科急诊室（EPU）入院，其中70名（25%）出现黄疸，其中64名（95%）血清胆红素高于170μmol/L。与在医院出生并定期接受随访的婴儿相比，院外出生的婴儿黄疸更严重，核黄疸发生率更高。核黄疸发生率分别为20.3%和2.6%。两组黄疸新生儿的病因模式相似。败血症（50%）和葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症（40%）是主要病因。接触传统草药、催产素诱导/加强分娩、头颅血肿和部落发病率未起到统计学上的显著作用。未发现由Rh血型不合引起的黄疸。将这项双前瞻性研究的结果与尼日利亚该中心和其他中心以前的研究结果进行了比较。
